Research Center for Experimental Modeling of Human Disease

Department of Advanced SciencesDivision of Integrated Omics Research

Staff

Aim and Research topics

In Division of Integrated Omics Research, the department is equipped with advanced state-of-the-art instruments such as mass spectrometers, microarray instruments, and DNA sequencers, and is working to elucidate the pathogenic mechanisms of various diseases that we can suffer during our lifetime through genome and protein analysis. Through joint research with domestic and overseas researchers, we are working toward the development of new treatments for diseases in the fields of medicine and life sciences, and the realization of social application of agricultural, forestry, and fishery products in the fields of science and agriculture. We are also working on the development of a new business model for the future.

High depth proteome analysis using diverse samples (Nishiuchi Lab)

Using various samples such as animal and plant tissues, secreted proteins of pathogens, clinical specimens, and archaeological samples, we construct highly sensitive proteomics experimental systems to search for and identify proteins involved in target biological phenomena, including post-translational modifications.

Development of technology to reduce pathogen-derived mycotoxins in wheat (Nishiuchi Lab)

Red mold of wheat produces mycotoxins, which can cause food poisoning in humans and livestock from infected wheat-derived foods. In order to reduce mycotoxin production, we are developing a new technology for the control of red mold using genome editing technology and natural products.

Regulation of Gene Expression by Chromosome Pairing ~Study using 15q duplication syndrome model cells~ (Horike Laboratory)

Many chromosome number abnormalities, such as Down syndrome, 13-trisomy, 18-trisomy, and Turner syndrome, show mental retardation despite their different chromosomes. In addition, with recent advances in genome analysis technology, numerous genomic copy number variations have been identified in patients with neurodevelopmental disorders. These findings suggest that nuclear arrangement of genes and higher-order chromatin structure are important for normal brain development. Therefore, we are analyzing how the disruption of global gene expression regulation by nuclear positioning of genes and higher-order chromatin structure by establishing the 15q duplication model cells.